Title: Lower CD28+ T cell proportions were associated with CMV-seropositivity in patients with Hashimoto’s thyroiditis Short title: Lower CD28+ T cell proportions in patients with Hashimoto’s thyroiditis Authors:

نویسندگان

  • Martina Prelog
  • Jörn Schönlaub
  • Reinhard Würzner
  • Christian Koppelstaetter
  • Giovanni Almanzar
  • Andrea Brunner
  • Rupert Prommegger
  • Gabriele Häusler
  • Klaus Kapelari
  • Wolfgang Högler
چکیده

word counts: 272 Text body word counts: 2731

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Lower CD28+ T cell proportions were associated with CMV-seropositivity in patients with Hashimoto’s thyroiditis

BACKGROUND Alterations in the naive T cell subpopulations have been demonstrated in patients with T cell mediated autoimmune disorders, reminiscent of immunological changes found in the elderly during immunosenescence, including the switch from CD45RA + to CD45RO + T cells and decreased thymic function with increased compensatory proliferative mechanisms, partly associated with latent Cytomegal...

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Impact of HIV on CD8+ T Cell CD57 Expression Is Distinct from That of CMV and Aging

BACKGROUND Chronic antigenic stimulation by cytomegalovirus (CMV) is thought to increase "immunosenesence" of aging, characterized by accumulation of terminally differentiated CD28- CD8+ T cells and increased CD57, a marker of proliferative history. Whether chronic HIV infection causes similar effects is currently unclear. METHODS We compared markers of CD8+ T cell differentiation (e.g., CD28...

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A Retrospective Study on Patients who Have Undergone Surgery For Goiter with Final Pathological Diagnosis of Hashimoto’s Thyroiditis

Hashimoto’s Thyroiditis is common cause of hypothyroidism with goiter in Iodine sufficient regions due to chronic auto immune disease. Patients with Hashimoto’s Thyroiditis present either a small diffuse goiter or markedly enlarged firm gland mimicking malignancy. These patients may have an associated dominant nodule, most commonly a benign colloid, adenomatous nodule, nodular thyroiditis, or a...

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Autoimmune Thyroiditis in Patients with Myelopathy/Tropical Spastic Paraparesis and in HTLV-1 Carriers in Mashhad, Northeastern Iran

There are some reports about the association of autoimmune thyroid diseases with human T-cell leukemia virus type-I (HTLV-I) infection. The objective of this study was to estimate the seroprevalence rates of antithyroid antibodies in HTLV-I carriers and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients in Mashhad, northeastern Iran, in order to determine any associati...

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Struma Ovarii With the Coexistence of Hashimoto’s Thyroiditis: A Case Report

Background: Struma ovarii (SO) is a rare phenomenon. In addition, it can be identified from the histological assessment and may show the characteristics of Hashimoto’s thyroiditis in rare cases. In several cases, malignant stroma ovarii is found to produce hyperthyroidism while very few cases are reported with Hashimoto’s thyroiditis. The present study reported SO co-incident with Hashimoto’s t...

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تاریخ انتشار 2012